Trials / Completed
CompletedNCT03511157
Ischemic Preconditioning Claudication Study
Walking Capacity of Patients With Claudication in Lower Extremities Following Ischemic Preconditioning
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 24 (actual)
- Sponsor
- Medical College of Wisconsin · Academic / Other
- Sex
- All
- Age
- 18 Years – 80 Years
- Healthy volunteers
- Not accepted
Summary
This study proposes ischemic preconditioning (IPC) as a novel intervention to improve walking distance in patients with intermittent claudication.
Detailed description
This study proposes ischemic preconditioning (IPC) as a novel intervention to improve walking distance in patients with intermittent claudication. Peripheral arterial disease (PAD) is a circulatory condition in which large supply blood vessels narrow, reducing oxygen and nutrient distribution to peripheral tissues. IPC protects against tissue damage caused by ischemia and can improve functional capacity in patients recovering from stroke; however, the benefit of ischemic preconditioning in patients with peripheral arterial disease remains unclear. The investigators predict that ischemic preconditioning (IPC) will delay claudication onset time (COT), increase peak walking time (PWT) and improve muscle strength in patients with intermittent claudication. The investigators will determine whether IPC improves claudication onset time (COT) and peak walking time (PWT) in patients with intermittent claudication. A motorized treadmill will be employed to assess COT and PWT. The investigators will determine whether IPC can improve muscle strength and time to pain onset in the affected leg of patients with intermittent claudication. These metrics will be assessed quantitatively using a Biodex™ dynamometer.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | Ischemic Preconditioning | See Ischemic Preconditioning Experimental group description |
| OTHER | Control Group | See Control group description |
Timeline
- Start date
- 2018-06-14
- Primary completion
- 2022-12-13
- Completion
- 2022-12-13
- First posted
- 2018-04-27
- Last updated
- 2022-12-14
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT03511157. Inclusion in this directory is not an endorsement.