NCT03507634

Opioid Free Anesthesia in Bariatric Surgery

Opioid Free Anesthesia in Bariatric Surgery: A Prospective, Double-blinded, Randomized, Controlled Clinical Trial

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 80 (actual)
• Sponsor: Lebanese American University · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

This study compares the intraoperative opioid free anesthesia approach in laparoscopic bariatric surgery to a conventional opioid- based anesthesia. Half of participants will receive opioid free anesthesia with dexmedetomidine, lidocaine and ketamine while the other half will receive opioid based anesthesia with fentanyl, remi-fentanyl and ketamine

Detailed description

Since optimal analgesia for the obese patients undergoing bariatric surgeries has always been challenging, and knowing the comorbidities and physiological changes in this population, use of opioid-sparing agents during anesthesia has attracted substantial research.the use of opioids in the perioperative period in obese patients is associated with an increased risk of complications . They are especially more sensitive to the respiratory depressant effect of opioids , thus any analgesic alternative without further compromising airway tone would be a desirable choice. Dexmedetomidine is a selective alpha-two adrenergic receptor agonist that has antinociceptive, analgesic and sedative properties, without compromising airway tone and reflexes . Lidocaine, a local anesthetic that has been shown to be an effective multimodal strategy to minimize postoperative pain was evaluated in one study involving obese patients undergoing bariatric surgery. Its usage was associated with an improved quality of recovery compared to placebo .

Conditions

• Opioid Use
• Postoperative Pain
• Postoperative Nausea and Vomiting
• Bariatric Surgery Candidate

Interventions

Type	Name	Description
DRUG	Opioid free Anesthesia dexmedetomidine and lidocaine	Opioid free anesthesia with dexmedetomidine and lidocaine
DRUG	Opioid based anesthesia Fentanyl and Remifentanyl	Opioid based anesthesia with Fentanyl and Remifentanyl

Timeline

• Start date: 2018-04-11
• Primary completion: 2020-06-30
• Completion: 2020-06-30
• First posted: 2018-04-25
• Last updated: 2020-09-29

Locations

1 site across 1 country: Lebanon