NCT03497741

Predictive Value of Procalcitonin for Bacteremia in the ICU

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 170 (actual)
• Sponsor: Rijnstate Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Association between plasma procalcitonin levels and positive blood cultures in critical illness patients in the ICU.

Detailed description

Rationale: Association of procalcitonin levels and blood cultures in critical illness patients on the ICU. Objective: Procalcitonin is an acute phase protein. As part of the acute phase response, procalcitonin is produced during sepsis. Previous research shows that procalcitonin is a biomarker for bloodstream infection. However, there is still little known about the value of procalcitonin in diagnostics for micro-organism underlying a sepsis in ICU patients. In modern practice, blood cultures are taken when a patient is septic to determine the responsible micro-organism. When procalcitonin is a predictive value for bacteremia in the ICU, the number of blood cultures can be reduced. Study design: An observational cohort study intervention: for each patient in the ICU blood cultures were taken, the procalcitonin level was determined. During 6 months 150 patients will be included. Main study parameters/endpoints: this study will examine the predictive value of procalcitonin in blood cultures on the ICU.

Conditions

• Sepsis
• Procalcitonin

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	procalcitonin measurement	For each patient were blood cultures were taken, a procalcitonin level was determined

Timeline

• Start date: 2017-10-01
• Primary completion: 2019-01-01
• Completion: 2019-03-01
• First posted: 2018-04-13
• Last updated: 2024-06-21

Locations

1 site across 1 country: Netherlands