NCT03495999

Hyperuricemia and Left Ventricular Diastolic Function

Associations and Plausibility Among Left Ventricle Diastolic Function, Serum Uric Acid and Inflammatory Biomarkers in Individuals With Cardiometabolic Risks - A Prospective Observational Study

• Status: Terminated
• Phase: —
• Study type: Observational
• Enrollment: 67 (actual)
• Sponsor: National Defense Medical Center, Taiwan · Academic / Other
• Sex: All
• Age: 20 Years – 75 Years
• Healthy volunteers: —

Summary

Metabolic syndrome and hyperuricemia were both associated with inflammation, leading to diversities of cardiovascular disease such as left ventricular diastolic dysfunction, but the relationship among these entities remained unclear. The aim of the present study focuses on the association among hyperuricemia, diastolic dysfunction and inflammatory biomarkers in apparently healthy individuals with metabolic syndrome

Detailed description

Apparently healthy individuals with metabolic syndrome were prospectively and consecutively enrolled since August 2017. Blood samples were obtained after participants are fasting for at least 12 hours, including serum uric acid, high-sensitivity C-reactive protein, high-sensitivity interleukin-6, tumor necrotizing factor alpha, fasting glucose, glycosylated hemoglobin, insulin, lipid profile, creatinine, alanine aminotransferase, sodium, potassium, and calcium. All echocardiographic parameters were measured in accordance with the American Society of Echocardiography guidelines.

Conditions

• Hyperuricemia
• Metabolic Syndrome
• Left Ventricular Diastolic Dysfunction

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	hyperuricemia	serum uric acid of 7mg/dl or more in men or 6mg/dl or more in women

Timeline

• Start date: 2017-08-01
• Primary completion: 2017-12-15
• Completion: 2018-04-03
• First posted: 2018-04-12
• Last updated: 2018-04-12

Locations

1 site across 1 country: Taiwan