NCT03488693

Regional Radiotherapy in Biomarker Low-Risk Node Positive and T3N0 Breast Cancer

TAILOR RT: A Randomized Trial of Regional Radiotherapy in Biomarker Low-Risk Node Positive and T3N0 Breast Cancer

• Status: Recruiting
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 2,140 (estimated)
• Sponsor: Canadian Cancer Trials Group · Network
• Sex: Female
• Age: 35 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to compare the effects on low risk breast cancer receiving usual care that includes regional radiation therapy, with receiving no regional radiation therapy. Researchers want to see if not giving this type of radiation treatment works as well at preventing breast cancer from coming back.

Detailed description

Women with node positive breast cancer normally will receive endocrine therapy and some may receive chemotherapy to help prevent the cancer from coming back. Many women will also receive radiotherapy to the whole breast/chest area and the surrounding lymph glands (called regional radiotherapy). No one really knows whether patients with low risk breast cancer need to receive regional radiotherapy. Some women may be getting regional radiotherapy who do not need it. These women may be exposed to the side effects of their treatment without benefit.

Conditions

• Breast Cancer

Interventions

Type	Name	Description
RADIATION	Radiation	Radiotherapy given
OTHER	No Radiation	No radiotherapy given

Timeline

• Start date: 2018-10-16
• Primary completion: 2027-09-01
• Completion: 2027-12-30
• First posted: 2018-04-05
• Last updated: 2026-04-14

Locations

483 sites across 2 countries: United States, Canada

Regulatory

• FDA-regulated device study