NCT03487978

Longitudinal Changes of Brain Functional Connectivity in Migraine

The Migrainous Brain: a Prospective Research for Longitudinal Changes of Brain Networks in Migraine

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 100 (actual)
• Sponsor: Samsung Medical Center · Academic / Other
• Sex: All
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to identify a core fMRI feature that determines migrainous brain and plastic fMRI features that changes with longitudinal courses of migraine.

Detailed description

Migraine is associated with functional alterations in specific brain networks. The investigators aimed to identify network abnormalities which remain unchanged throughout the longitudinal course of migraine. The investigators also aimed to identify networks which change in association with changes in migraine frequency and associated psychiatric conditions. The investigators expect these can serve as neuroimaging biomarkers for diagnosis of migraine brain and monitoring of disease severity.

Conditions

• Migraine

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	resting-state functional MRI	1. To ensure inter-ictal fMRI, confirm that the subject has no migraine for at least 48 hours before the procedure. 2. Record the time difference between the date on the day of fMRI and the date of the last headache attack and record whether the headache on the day of fMRI is absent or not. 3. On the third day after MRI, examine whether the subject has headache or not.

Timeline

• Start date: 2017-07-24
• Primary completion: 2022-02-28
• Completion: 2023-02-28
• First posted: 2018-04-04
• Last updated: 2020-03-20

Locations

1 site across 1 country: South Korea