NCT03485339

Substance Misuse To Psychosis for Ketamine (SToP-K)

Substance Misuse To Psychosis for Ketamine (SToP-K) -Who is At Risk? A Case-Control Study in Ketamine and Non-Ketamine-Using Substance Abusers

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 162 (actual)
• Sponsor: The University of Hong Kong · Academic / Other
• Sex: All
• Age: 12 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Evidence suggests that repeated or chronic ketamine use, as compared to acute ketamine users, posed a higher clinical risk of developing psychotic disorders, potentially related to the underlying chronic N-methyl-D-aspartate receptor (NMDAR) dysfunction, and a higher risk of suffering from schizophrenia particularly in those genetically susceptible, or genetically predisposed ketamine abusers. With ketamine infusion rises as a emerging hope as an acute treatment for depression and suicidality under the shadow of unknown longer term psychotomimetic effects peculiarly amongst repeated or chronic use, the current case-control study aims to investigate: a) if repeated or chronic ketamine use is associated with an increased risk of psychosis by comparing those ketamine abusers with and without psychosis, and to those non-ketamine-using drug abusers with psychosis; and b) if genetic predisposition from single nucleotide polymorphisms are associated with risk of psychosis in ketamine abusers.

Conditions

• Ketamine Abuse
• Psychotic Disorders
• Substance Use Disorders
• Schizophrenia
• Genetic Predisposition

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	genome testing	blood sampling via venipuncture

Timeline

• Start date: 2018-06-12
• Primary completion: 2020-03-01
• Completion: 2020-04-01
• First posted: 2018-04-02
• Last updated: 2020-07-31

Locations

2 sites across 1 country: Hong Kong