NCT03479203

Acute Effects of E-Cigarette Aerosol Inhalation

Acute and Long-term Effects of E-Cigarette Aerosol Inhalation on Biomarkers of Endothelial Function and Vascular Reactivity

• Status: Completed
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 31 (actual)
• Sponsor: University of Pennsylvania · Academic / Other
• Sex: All
• Age: 18 Years – 35 Years
• Healthy volunteers: Accepted

Summary

This study comprises a portion of a larger study designed to compare results of vascular function in non-smokers to vascular function in healthy smokers chronically exposed to nicotinized electronic cigarette aerosol versus conventional cigarettes.

Detailed description

Here, we 1) investigate the acute effects of non-nicotinized e-cigarette aerosol inhalation in nonsmokers in terms of blood-based markers of inflammation and oxidative stress, and 2) evaluate their association with hemodynamic-metabolic MRI parameters quantifying peripheral vascular reactivity, cerebrovascular reactivity, and aortic stiffness.

Conditions

• Endothelial Dysfunction
• Biochemical Markers

Interventions

Type	Name	Description
DRUG	Electronic Cigarette Aerosol	16 two-second-long puffs from a non-nicotinized electronic cigarette.

Timeline

• Start date: 2018-05-22
• Primary completion: 2022-08-31
• Completion: 2022-08-31
• First posted: 2018-03-27
• Last updated: 2024-05-08
• Results posted: 2024-05-08

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study