NCT03474120

Prospective Genetic Study in Patients With Ovarian Insufficiency

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 300 (estimated)
• Sponsor: The First Affiliated Hospital of Anhui Medical University · Academic / Other
• Sex: Female
• Age: —
• Healthy volunteers: Not accepted

Summary

genetic screening and etiological analysis was conducted on patients with ovarian insufficiency and decline in ovarian reserve. All patients were enrolled in the IVF-treated and non-IVF-treated groups, followed up for long-term treatment outcomes and genomic screening.

Detailed description

The cause of ovarian insufficiency and decline in ovarian reserve are not clear, but most researchers think the probable causes are mainly three aspects: chromosomal abnormalities, genetic factors and autoimmune diseases，But the majority of patients with normal chromosome karyotype analysis. The screening of pathogenic genes in patients with normal karyotype is the focus of current premature ovarian insufficiency(POI) and decline in ovarian reserve(DOR) etiology, to further explain the pathogenesis of patients, improve the diagnosis of those diseases and Clinical treatment.

Conditions

• Premature Ovarian Failure
• Primary Ovarian Insufficiency
• Ovarian Dysgenesis
• Diminished Ovarian Reserve

Interventions

Type	Name	Description
PROCEDURE	IVF treatment	Relationship between IVF treatment outcome and genotypes in POI//DOR/ovarian dysgenesis patients

Timeline

• Start date: 2018-04-20
• Primary completion: 2023-01-24
• Completion: 2023-12-24
• First posted: 2018-03-22
• Last updated: 2021-02-21

Locations

1 site across 1 country: China