NCT03470038

Interaction Between NGF and Acute Exercise-induced Ischemia

The Interaction Between NGF-induced Muscle Sensitivity and Acute Exercise-induced Ischemia

• Status: Completed
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 21 (actual)
• Sponsor: Aalborg University · Academic / Other
• Sex: All
• Age: 18 Years – 55 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to investigate pain evoked responses and facilitation of NGF-induced mechanical muscle hyperalgesia over time following an acute exercised-induced ischemic condition in a NGF-sensitized muscle.

Detailed description

Assessing evoked pain responses and muscle hyperalgesia following contractions during acute ischemia in a NGF-sensitized muscle may clarify whether an interaction between NGF sensitization and acidic stimulation exist. It is hypothesized that acute ischemic exercise with the NGF-sensitized TA muscle, in contrast to ischemic exercise in a non-sensitized would: 1) potentiate pain-evoked responses, and 2) facilitate NGF-induced muscle hyperalgesia.

Conditions

• Hyperalgesia
• Pain Response
• Healthy Subjects

Interventions

Type	Name	Description
DRUG	NGF	Intramuscular injection
DRUG	Isotonic saline	Intramuscular injection

Timeline

• Start date: 2018-03-15
• Primary completion: 2018-05-15
• Completion: 2018-06-15
• First posted: 2018-03-19
• Last updated: 2019-02-15

Locations

1 site across 1 country: Denmark