NCT03459027

Nitrate Supplementation and Muscle Blood Flow

Nitric Oxide Bioavailability and Dynamics of Blood Flow and Vasodilation With Age

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 10 (actual)
• Sponsor: University of Iowa · Academic / Other
• Sex: All
• Age: 60 Years – 80 Years
• Healthy volunteers: Accepted

Summary

The main purpose of this study is to evaluate the effects of an acute dose of dietary nitrate in the form of beetroot juice on skeletal muscle blood flow in response to dynamic knee extension exercise in healthy older adults. All subjects will receive active (rich in dietary nitrate) or placebo (devoid of nitrate) supplementation.

Detailed description

Dietary nitrate (beetroot juice) is reduced to nitrite and nitric oxide within the digestive system of humans. Nitric oxide exerts potent vasodilator effects, which have been shown to reduce blood pressure and enhance exercise economy in humans. This pressure reducing effect may have implications within the regulation of blood flow during dynamic exercise in older adults.

Conditions

• Vasodilation
• Blood Pressure
• Active Hyperemia
• Aging

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Super Beets	Nitrate rich beetroot powder (10g) acutely
DIETARY_SUPPLEMENT	Beetroot powder	Nitrate devoid beetroot powder (10g) acutely

Timeline

• Start date: 2017-10-10
• Primary completion: 2018-02-08
• Completion: 2018-02-08
• First posted: 2018-03-08
• Last updated: 2019-01-09

Locations

1 site across 1 country: United States