NCT03447457

Early Initiation of High-flow Nasal Cannula Oxygen Therapy in Patients With Acute Respiratory Failure in the Emergency Department: A Before-after Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 102 (actual)
• Sponsor: Poitiers University Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The aim of the study is to compare the efficiency on respiratory failure regression of high-flow nasal oxygen therapy versus standard oxygen in patients admitted to the ED for de novo acute respiratory failure.

Detailed description

Prospective observational before-after study at the ED in two French centers. Selection of patients with acute hypoxemic respiratory failure at the ED. Application of oxygen strategy according to the period: * before period: standard oxygen delivered through nasal cannula, face mask or non-rebreathing reservoir mask, with a flow rate adjusted to maintain a pulse oxymetry of at least 92%. * after period: high-flow oxygen therapy continuously applied via large-bore nasal prongs with a gas flow rate of 50 L/min and a FiO2 adjusted to maintain a pulse oxymetry at least 92%.

Conditions

• Acute Respiratory Failure

Interventions

Type	Name	Description
DEVICE	High-flow oxygen	HFNC is continuously applied via large-bore nasal prongs with a gas flow rate of 50 L/min and a FiO2 adjusted to maintain a pulse oxymetry at least 92%
DEVICE	Standard oxygen	nasal cannula, face mask or non-rebreathing reservoir mask

Timeline

• Start date: 2015-12-01
• Primary completion: 2017-05-30
• Completion: 2017-05-30
• First posted: 2018-02-27
• Last updated: 2018-02-27

Locations

2 sites across 1 country: France