NCT03436108

Bisphenol Role in the Pathogenesis of PCOS

Role of Bisphenol A (BPA) in the Pathogenesis of the Polycystic Ovary Syndrome

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 220 (actual)
• Sponsor: Aljazeera Hospital · Academic / Other
• Sex: Female
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

Polycystic ovary syndrome (PCOS) is the most common and the most heterogeneous endocrine disorder in premenopausal women. Its prevalence is estimated from 5 to 10% depending on the diagnosis' criteria . Apart from signs of hyperandrogenism such as acne, hirsutism and hair loss; women with PCOS usually present with menstrual irregularities and fertility problems ..

Detailed description

Bisphenol A is formed from acetone and phenol, it is used in production of epoxy resin, polyster resins and polyvarbonate resins. Epoxy resins are used in plastics, adhesives, and structural composites . Humans are at the end of the food chain, thus they are exposed to the highest doses of these compounds. EDs have been detected in human adipose tissue and biological fluids such as: serum, urine, milk and amniotic fluid . Additionally, it has been proven that BPA can also directly stimulate androgen synthesis in the ovarian theca-interstitial cells. A correlation between increased serum testosterone levels observed in women with PCOS with serum BPA concentrations has also been found .

Conditions

• PCOS

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Measurement of Bisphenol in urine	to see level of this material in blood of women

Timeline

• Start date: 2019-02-10
• Primary completion: 2019-12-01
• Completion: 2020-01-20
• First posted: 2018-02-19
• Last updated: 2022-01-14

Locations

1 site across 1 country: Egypt