Trials / Completed
CompletedNCT03426241
Effect of Smoking on the Expression of Gelatinases in Chronic Periodontitis
The Effect of Smoking on the Expression of Gelatinases in Chronic Periodontitis: A Cross-sectional Study
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 80 (actual)
- Sponsor
- Baskent University · Academic / Other
- Sex
- All
- Age
- 16 Years – 62 Years
- Healthy volunteers
- Accepted
Summary
This study comparatively evaluate the expressions of MMP-2 and MMP-9 in smoker vs non-smoker chronic periodontitis patients as well as periodontally healthy subjects. the hypothesis of this study was that smoking may interfere with periodontal disease by effecting MMP-2 and MMP-9 expressions.
Detailed description
Smokers have greater risk for developing periodontal disease and smoking is highly correlated with greater marginal bone loss. Matrix metalloproteinases (MMP) play a major role in periodontal tissue destruction. MMP-2 and MMP-9, called gelatinases, are one of the major MMPs that plays important roles in periodontitis. To date, several studies showed the increased levels of gelatinases in periodontal disease and only a limited number of study investigated the effect of smoking on gelatinases. However, no previous study has directly investigated the possible relationship between smoking and gingival tissue gelatinases expressions (MMP-2 and MMP-9) in chronic periodontitis (CP) patients relative to periodontally healthy subjects. Therefore this study is conducted to comparatively evaluate the expressions of MMP-2 and MMP-9 in smoker vs non-smoker chronic periodontitis patients as well as periodontally healthy subjects. the of this study hypothesis was that smoking may interfere with periodontal disease by effecting MMP-2 and MMP-9 expressions.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | no intervention | this is cross-sectional study |
Timeline
- Start date
- 2010-02-10
- Primary completion
- 2012-12-29
- Completion
- 2012-12-30
- First posted
- 2018-02-08
- Last updated
- 2018-02-08
Source: ClinicalTrials.gov record NCT03426241. Inclusion in this directory is not an endorsement.