NCT03419247

Molecular Profiling of Advanced Biliary Tract Cancers

Comprehensive Molecular Profiling of Advanced Biliary Tract Cancers (BTC) for Better Treatment Selection: A Prospective Study (COMPASS B)

• Status: Withdrawn
• Phase: N/A
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: University Health Network, Toronto · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This is a study where fresh tumor tissue and blood samples will be collected from patients with advanced biliary tract cancer who will be undergoing 1st line therapy with gemcitabine or fluorouracil (5-FU) regimens to see how useful it is to look for changes and characteristics in genes (molecules that contain instructions for the development and functioning of the cells) and the genes within the tumour to find characteristics that may be useful in choosing treatments for patients in the future.

Detailed description

Changes (mutations) in genes have been shown to be an important characteristic in cancers. Looking at differences in genes in patients with unresectable or metastatic biliary tract cancer and comparing this information with response to their initial chemotherapy treatment may help to learn which treatments may be better for certain patients after initial treatment.

Conditions

• Biliary Tract Cancer

Interventions

Type	Name	Description
PROCEDURE	Fresh tumor tissue biopsy	A type of surgical procedure that will use a thin needle to remove a sample of tumor tissue.
PROCEDURE	Blood draw	Blood will be taken by a needle from a vein.
PROCEDURE	Archival tumor tissue collection	A sample of tumor tissue that was taken by biopsy or surgery before agreeing to take part in this study will be collected.

Timeline

• Start date: 2020-01-01
• Primary completion: 2022-01-02
• Completion: 2023-01-02
• First posted: 2018-02-01
• Last updated: 2021-04-01