NCT03416621

Project Q Pilot: Smoking Cessation for Light Smokers

Project Q Pilot: Examining Different Treatment Modalities to Maximize Cessation Efforts for Light Smokers

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 31 (actual)
• Sponsor: Duke University · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

The purpose of this pilot study is to evaluate the feasibility, acceptability, and preliminary efficacy of an intervention to promote smoking cessation among light smokers.

Detailed description

The three-arm randomized controlled trial compares Arm 1) standard smoking cessation plus support text messages, 2) enhanced cue exposure treatment (lab-based + interactive SMS texting) + D-cycloserine placebo, Arm 3)will include a combination of cognitive behavioral cessation counseling, enhanced cue exposure treatment (lab-based + interactive SMS texting) and a cognitive-enhancing drug - D-cycloserine. In addition to an in-person screening visit, we will conduct three in-person treatment visits and an inperson follow-up visit.

Conditions

• Tobacco Use Cessation

Interventions

Type	Name	Description
BEHAVIORAL	Cognitive behavioral cessation counseling	Standard smoking cessation plus support text messages
BEHAVIORAL	Counseling and placebo drug intervention	Enhanced cue exposure treatment (lab-based + interactive SMS texting) + DCS placebo
DRUG	Counseling and active drug intervention	Enhanced cue exposure treatment (lab-based + interactive SMS texting)+ active DCS. In addition to an in-person, screening visit, we will conduct three in-person treatment visits and an in-person follow-up visit.

Timeline

• Start date: 2018-05-17
• Primary completion: 2020-02-29
• Completion: 2020-02-29
• First posted: 2018-01-31
• Last updated: 2021-03-29
• Results posted: 2021-02-24

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study