Trials / Completed
CompletedNCT03410745
Cartilage Adaptation and Response to Interleukins and Exercise
The Effect of Exercise on the Collagen Synthesis and Cytokine Response in Human Cartilage Tissue With Osteoarthritis
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 32 (actual)
- Sponsor
- Bispebjerg Hospital · Academic / Other
- Sex
- All
- Age
- 40 Years – 90 Years
- Healthy volunteers
- Not accepted
Summary
This study will examine the effect of exercise on the turnover of collagen in articular cartilage and the content of cytokines in the synovial fluid from human adults with osteoarthritis.
Detailed description
By using stabile isotope labelling, this study will track the formation and destination of newly formed cartilage collagen in adult humans scheduled for knee replacement surgery due to osteoarthritis. The collagen formation as well as the effect on the cytokine content of the synovial fluid will be examined both at rest and in response to 4 weeks of exercise/training. Overall the project aims to improve the basic understanding of cartilage development and function in relation to osteoarthritis prevention.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| BEHAVIORAL | Exercise. | Moderate to heavy intensity resistance exercise consisting of leg press. |
Timeline
- Start date
- 2018-02-21
- Primary completion
- 2019-09-10
- Completion
- 2019-09-10
- First posted
- 2018-01-25
- Last updated
- 2019-09-25
Locations
1 site across 1 country: Denmark
Source: ClinicalTrials.gov record NCT03410745. Inclusion in this directory is not an endorsement.