NCT03407924

Exercise and Rehabilitation After Traumatic Brain Injury

Effects of Aerobic Exercise and Rehabilitation After Traumatic Brain Injury

• Status: Unknown
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 120 (estimated)
• Sponsor: Centre for Neuro Skills · Industry
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to examine the effects of exercise on recovery after traumatic brain injury. Investigators will determine if exercise enhances rehabilitation by increasing substances (proteins) that can facilitate recovery.

Detailed description

Exercise-based therapies can promote recovery of function and are easily implemented in the clinical rehabilitation setting. This study will determine if exercise facilitates recovery by improving markers of neuroplasticity and decreasing neuroinflammatory responses. The investigators will also determine if variations in genes involved in neuroplasticity, memory and inflammation influence the responsiveness to exercise and rehabilitation. Particular genetic polymorphisms involved in neuroplasticity and inflammatory responses will be evaluated. Recovery will be determined by assessing cognitive function, life quality and balance.

Conditions

• Traumatic Brain Injury

Interventions

Type	Name	Description
OTHER	Aerobic Exercise (AER)	Aerobic exercise will be performed with a treadmill or stationary tandem bike 3 times per week. Each exercise session will take about 30 minutes plus 5 to 10 min of warm-up and cool-down. Participants will wear a safety harness.
OTHER	Rehabilitation	Rehabilitative program is focused on completion of activities of daily living, initiation, appropriate behavior and community integration for five days per week at the Centre for Neuro Skills.

Timeline

• Start date: 2016-06-01
• Primary completion: 2020-03-01
• Completion: 2022-03-01
• First posted: 2018-01-23
• Last updated: 2018-01-30

Locations

1 site across 1 country: United States