NCT03403361

Dual-Energy CT on Plan Quality, Dose-delivery Accuracy, and Simulated Outcomes of Patients Treated With Proton or Photon Therapy

A Virtual Clinical Trial to Assess the Impact of Dual-Energy CT on Plan Quality, Dose-delivery Accuracy, and Simulated Outcomes of Patients Treated With Proton or Photon Therapy

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 36 (actual)
• Sponsor: Washington University School of Medicine · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The aim of this protocol is to refine the accuracy of proton beam therapy (PT) by the use of dual energy computed tomography (DECT), in conjunction with novel iterative image reconstruction algorithms, to more precisely determine the tissue properties through which the proton beam path travels.

Conditions

• Lung Cancer
• Brain Cancer
• Head and Neck Cancer

Interventions

Type	Name	Description
DEVICE	Siemens Somatom Definition Edge	In addition to acquiring medically-routine datasets, each patient subject will be scanned sequentially at two or three different beam energies (80 or 90 kVp, 100 kVp, 120 kVp, and 140 kVp) as part of this research study.
DEVICE	Philips Brilliance Big Bore CT/simulator	In addition to acquiring medically-routine datasets, each patient subject will be scanned sequentially at two or three different beam energies (80 or 90 kVp, 100 kVp, 120 kVp, and 140 kVp) as part of this research study.

Timeline

• Start date: 2018-06-01
• Primary completion: 2022-08-11
• Completion: 2022-08-11
• First posted: 2018-01-18
• Last updated: 2024-03-01
• Results posted: 2024-03-01

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated device study