NCT03398226

Bone Microstructure After Gastrectomy Evaluating by Using HR-pQCT

Chronological Change of Bone Microstructure After Gastrectomy

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 42 (estimated)
• Sponsor: Nagasaki University · Academic / Other
• Sex: All
• Age: 60 Years – 79 Years
• Healthy volunteers: Accepted

Summary

Osteoporosis after gastrectomy, which is characterized by both the loss of bone mass and the deterioration of bone architecture, is a serious complication in the long course after gastrectomy. The aim of the present study was to evaluate osteoporosis by using high-resolution peripheral quantitative computed tomography (HR-pQCT) in the long course after gastrectomy. In total gastrectomy and distal gastrectomy groups, at least 5 years should have elapsed since gastrectomy.

Detailed description

The patients after gastrectomy loss appetite and decrease the weight. Total gastrectomy especially cause severe sarcopenia and metabolic change. Osteoporosis after gastrectomy, which is characterized by both the loss of bone mass and the deterioration of bone architecture, is a serious complication in the long course after gastrectomy. The primary tools for assessing volumetric density and bone structure are quantitative computed tomography (QCT) and more recently, high-resolution peripheral quantitative computed tomography (HR-pQCT). However the validation of osteoporosis with HR-pQCT before and after gastrectomy remain elusive. The aim of the present study was to evaluate osteoporosis by using HR-pQCT before and after after endoscopic resection, distal gastrectomy, and total gastrectomy in the patients with gastric cancer.

Conditions

• Osteoporosis
• Sarcopenia
• Gastric Cancer

Timeline

• Start date: 2017-09-18
• Primary completion: 2020-03-31
• Completion: 2023-03-31
• First posted: 2018-01-12
• Last updated: 2018-01-17

Locations

1 site across 1 country: Japan