NCT03391609

Peri-operative Dexmedetomidine Infusion in Pre-eclamptic Patients

Peri-operative Dexmedetomidine Infusion in Mild Pre-eclamptic Patients Undergoing Elective Cesarean Section Under General Anesthesia

• Status: Completed
• Phase: Phase 2 / Phase 3
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: Assiut University · Academic / Other
• Sex: Female
• Age: 19 Years – 40 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to investigate the effects of dexmedetomidine infusion on the stress response to intubation, postoperative analgesia, and renal functions (urinary output \[UOP\], creatinine and glomerular filtration rate \[GFR\]) in preeclamptic patient.

Conditions

• Pre-Eclampsia

Interventions

Type	Name	Description
DRUG	placebo infusion	Caesarian section will be performed under standard general anesthesia plus pre and intra operative saline infusion (placebo) in the same rate as dexmedetomedine starting 15 minutes before induction of general anesthesia and continue till peritoneum closure.
DRUG	Dexmedetomidine infusion	Caesarian section will be performed under standard general anesthesia plus pre and intra operative Dexmedetomidine infusion in a dose of 0.5mic/kg/hour starting 15 minutes before induction of general anesthesia and continue till peritoneum closure.

Timeline

• Start date: 2017-06-18
• Primary completion: 2018-11-01
• Completion: 2019-01-01
• First posted: 2018-01-05
• Last updated: 2019-02-26

Locations

1 site across 1 country: Egypt

Regulatory

• FDA-regulated drug study