NCT03388450

Omega-3 Fatty Acid for Critically Ill Patients.

Effect of Enteral Nutrition With Omega-3 Fatty Acid in Critically Ill Septic Patients.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 110 (actual)
• Sponsor: Menoufia University · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

Sepsis is the most common reason for intensive care unit (ICU) admission. Sepsis flares up the systemic inflammatory response with its mediators. Sepsis treatment protocols have been established in many centres with immune nutrient as adjuvant treatment. Omega-3 fatty acid and other anti-oxidants formulae have been found to improve sepsis outcome. In most of the studies, immune nutrients were giving parenterally, however, nowadays the preferable route of feeding in critically ill patients is enterally. The present study was done to investigate the effect of enteral Omega-3 fatty acid in septic critically ill patients.

Detailed description

A hundred and ten critically ill septic patients were included in the study. Patients were divided into two groups fifty-five patients each. Group A received enteral nutrition supplemented with Omega-3 fatty acid and group B received enteral nutrition without Omega-3. Demographic data, sepsis characteristics, number of patients required invasive ventilation, ventilation days, ICU sequential organ failure assessment score (SOFA), organ failure free-days, haemodynamic failure free-days, ICU stay, ICU and hospital outcomes were recorded.

Conditions

• Sepsis

Interventions

Type	Name	Description
DRUG	Omega 3	Enteral 1000 mg omega 3 fatty acid.
DRUG	Placebo	Enteral nutrition without omega 3 fatty acid.

Timeline

• Start date: 2015-01-15
• Primary completion: 2017-10-27
• Completion: 2017-11-30
• First posted: 2018-01-03
• Last updated: 2018-01-03