NCT03388385

Acute Effects of Intravenous Iron on Oxidative Stress and Endothelial Dysfunction in Non-dialysis CKD

The Effects of a Single Intravenous Iron Upon Vascular Endothelium and Some Parameters of Oxidative Stress in Patients With Non-dialysis Chronic Kidney Disease

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: Carol Davila University of Medicine and Pharmacy · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to investigate the effects of acute intravenous iron administration on the endothelial function in non-dialysis Chronic Kidney Disease stages G3-G5 patients with anemia and iron deficiency, in relation to changes in oxidative and nitrosative status.

Conditions

• Renal Anemia
• Iron Toxicity
• Oxidative Stress
• Endothelial Dysfunction

Interventions

Type	Name	Description
DRUG	Sodium Chloride 0.9% Intravenous Solution	Physiologic saline infusion will be infused in day 1.
DRUG	Ferinject	Ferric carboxymaltose will be infused in day 2.

Timeline

• Start date: 2017-09-20
• Primary completion: 2020-12-30
• Completion: 2022-12-20
• First posted: 2018-01-03
• Last updated: 2022-08-16

Locations

1 site across 1 country: Romania