NCT03371888

The Platelet-Rich Plasma in the Therapy of Temporomandibular Disorders

The Platelet -Rich Plasma in the Therapy of Temporomandibular Disorders

• Status: Completed
• Phase: Phase 2 / Phase 3
• Study type: Interventional
• Enrollment: 58 (actual)
• Sponsor: Medical University of Silesia · Academic / Other
• Sex: All
• Age: 23 Years – 42 Years
• Healthy volunteers: Accepted

Summary

The Platelet-Rich Plasma intramuscular injections into the masseter and temporalis muscle were performed to reduce painful temporomandibular disorder symptoms,such as myalgia, myofascial pain and myofascial pain with referrals. Patients(n=120) were randomly divided into two groups: experimental(n=60) and control group(n=60). In controls injections with 0,9% NaCl were performed. Pain intensity was measured with NPRS (numeriic pain rating scale, 0= no pain, 11= the worst pain that one can imagine) before(0 day), during(10 day) and after(20 day) the therapy with PRP injections.

Detailed description

Patients(n=120) attending The Department of Temporomandibular Disorders and Orthodontics at the Silesian Medical University Poland, Zabrze were enrolled to the study and randomly divided into one of two groups: experimental and control group. Platelet-Rich Plasma(PRP) was prepared for each patient and an intramuscular injections of 0,5 ml PRP into 6 points at each side were performed in experimental group. A follow-up appointment was made after 10 and 20 days and in each visit an injection of PRP or 0,9% NaCl was performed. Pain intensity was measured in NPRS(numeric pain rating scale) and collected data data were analyzed.

Conditions

• PRP
• Temporomandibular Disorder
• Myalgia
• Bruxism

Interventions

Type	Name	Description
BIOLOGICAL	Platelet-Rich Plasma intramuscular injections	A platelet-rich plasma intramuscular injections into the trigger points of painful muscles were performed.
BIOLOGICAL	Placebo Comparator: 0,9% NaCl intramuscular injections	A 0,9% NaCl intramuscular injections into the trigger points of painful muscles were performed.

Timeline

• Start date: 2017-12-07
• Primary completion: 2018-12-15
• Completion: 2019-01-01
• First posted: 2017-12-13
• Last updated: 2019-01-04

Locations

1 site across 1 country: Poland