NCT03369015

Effect of D-amphetamine on Reward Functioning

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 68 (actual)
• Sponsor: The University of Texas Health Science Center, Houston · Academic / Other
• Sex: All
• Age: 18 Years – 35 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to establish the dose-response curve for therapeutic doses of d-amphetamine on tasks of motivation and reward learning in the same participants and to use d-amphetamine as a dopaminergic probe to test newer theories about the role of dopamine in reward-related decision-making.

Conditions

• Anhedonia

Interventions

Type	Name	Description
DRUG	10 mg d-amphetamine	10 mg d-amphetamine dose given (double-blind) and behavioral tasks (EEfRT, PRT, ELT, CGT) administered.
DRUG	20mg d-amphetamine	20 mg d-amphetamine dose given (double-blind) and behavioral tasks (EEfRT, PRT, ELT, CGT) administered.
DRUG	Placebo	Placebo dose given (double-blind) and behavioral tasks (EEfRT, PRT, ELT, CGT) administered.

Timeline

• Start date: 2018-01-24
• Primary completion: 2019-05-23
• Completion: 2019-05-23
• First posted: 2017-12-11
• Last updated: 2020-11-05

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study