NCT03367650

Epidemiology and Genetics of the Amyotrophic Lateral Sclerosis in the French West Indies

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 70 (estimated)
• Sponsor: Centre Hospitalier Universitaire de la Guadeloupe · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The diagnosis and the follow-up of the patients reached of SLA is centralized, since a few years, at the the Caribbean Reference center of the rare neurological diseases (CERCA labélisé in 2006) in Martinique and at the Unity of coverage of the neuromuscular Diseases, SLA and the rare neurological diseases (create in 2010) in Guadeloupe. Several phenotypic characteristics seemed to us to take out again data collected during the follow-up of the patients (26 in Guadeloupe, since the creation of the unity) in particular patients' high proportion of exceptionally long evolution (more than 10 years). Besides, we diagnosed several cases (10 cases in Guadeloupe since 2000) of association SLA- Parkinsonien Syndrome. This association, considered as exceptional could establish a particular phenotypic entity which we would like to describe. We are interested also originally geographical of the patients, with the hypothesis that he could exist in the Antilles one or several geographical isolates of the disease allowing to lead a étiologique investigation in search of a possible genetic or environmental cause.

Detailed description

The amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive muscular paralysis due to degeneration of motor neurons in the primary motor cortex, corticospinal pathway, brain stem and spinal cord. The incidence is estimated at 2/100 000 per year and prevalence at approximately 4/100000. Various clinical forms are described. The disease is fatal is 3-5 years on average. The majority of cases are sporadic and of unknown origin but 5-10% are familial and present for 20% of them, mutations in the SOD1 (21q22.11) gene. Other genes have recently been implicated in ALS. Environmental toxic factors have been extensively researched. Beta-methylamino-L-alanine (BMAA), a neurotoxic nonprotein amino acid produced by most cyanobacteria, has been proposed to be the causative agent of the ALS-Parkinsonism Complex on the island of Guam in the Pacific Ocean. Epidemiology and clinical features of ALS have never been studied in Caribbean countries. The main purpose of the study will be to evaluate the incidence of ALS in Guadeloupe and Martinique. Secondary purposes will be: 1. to evaluate the presence of specific phenotypic features; 2. to establish he prognosis of different clinical forms; 3. to study the genes implicated in ALS and quantify theexposure to BMAA. Since 2000, the diagnosis of ALS is made in about 20 patients per year in Guadeloupe and Martinique(for a total population of 800000 inhabitants) but the incidence and the clinical presentation of ALS in the French West Indiesare unknown. The exceptional association of ALS and parkinsonism is regularly observed in Guadeloupe. We propose to perform a prospective descriptive and longitudinal epidemiological study to determine the incidence of ALSin the French West Indies. In parallel we will study the involvement of genetic andenvironmental toxic factors as etiological factor for this disease. Primary outcome: \- the impact of ALS in Guadeloupe and Martinique Secondary outcomes: * Assess the clinical characteristics (presence of phenotypic features?), * the prognosis of different clinical forms study, * to establish the genetic factors of the ALS and to search potential environmental factors

Conditions

• Amyotrophic Lateral Sclerosis

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Blood sample and environmental survey	The intervention corresponds to a 10 ml of Blood sample and an environmental survey.

Timeline

• Start date: 2014-05-13
• Primary completion: 2020-05-13
• Completion: 2023-05-13
• First posted: 2017-12-11
• Last updated: 2017-12-11

Locations

2 sites across 2 countries: Guadeloupe, Martinique