Trials / Terminated
TerminatedNCT03365076
Exercise for Improving Prostate Oxygenation in Prostate Tumors (Exipox)
Exercise for Improving Prostate Oxygenation in Prostate Tumors (Exipox)-Study - a Pilot Study Exploring Exercise as a Way of Improving Cure With Radical Radiotherapy
- Status
- Terminated
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 1 (actual)
- Sponsor
- University Hospital of North Norway · Academic / Other
- Sex
- Male
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
Previous research into metabolic and hypoxic markers has found evidence of preclinical impact of exercise on prostate tumor blood flow and oxygenation in rodents . As radiotherapy is a frequently used and effective therapy for and that sufficient oxygenation is decisive to the effect of radiotherapy, an underlying hypothesis that aerobic exercise might improve treatment efficacy of radiotherapy in prostate cancer is put forward. This study has a potential challenging intervention, but a potential very high gain as it includes active patient participation to significantly improve outcome of radical radiotherapy.
Detailed description
A randomized controlled trial with four to five weeks of moderate/high intensity aerobic exercise program compared with no intervention for 32 prostate cancer patients waiting for radical prostatectomy at the University Hospital of North Norway (UNN). 16 patients will undergo the intervention. The expression of the hypoxic marker pimonidazole in the prostate specimens of intervention groups and the control groups will be assessed. This method is considered a reliable tissue oxygenation measurement technique. These patients will also have their and blood flow and hypoxia measured in prostate cancers through magnetic resonance imaging (MRIs).
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | Physical activity | Aerobic physical activity as stated in Arm A |
Timeline
- Start date
- 2018-05-01
- Primary completion
- 2023-01-05
- Completion
- 2023-01-05
- First posted
- 2017-12-07
- Last updated
- 2023-01-09
Locations
1 site across 1 country: Norway
Source: ClinicalTrials.gov record NCT03365076. Inclusion in this directory is not an endorsement.