NCT03354624

Cortical Neuroplasticity by Muscle Pain of Pain-induced Plasticity

Cortical Neuroplasticity by Muscle Pain and Non-invasive Modulation of Pain-induced Plasticity

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 24 (actual)
• Sponsor: Aalborg University · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to investigate the sensory-motor cortical excitability response to delayed onset muscle soreness (DOMS) on Extensor Carpi Radialis (ECR) muscle during muscle hyperalgesia provoked by nerve growth factor (NGF).

Detailed description

The purpose of this study is to assess changes in sensory-motor cortical excitability during experimental muscle hyperalgesia across several days provoked by injections of nerve growth factor (NGF) into the Extensor Carpi Radialis (ECR) muscle and delayed onset muscle soreness (DOMS) of the ECR muscle. It was hypothesized that muscle hyperalgesia across several days would result in: i) Increased sensory cortical excitability, based on somatosensory evoked potentials by means of electrical stimulation of the radial nerve, (increase of central-parietal evoked-potential P45 and decrease of frontal evoked-potential N30); ii) Increased corticomotor excitability of a ECR (increase map volume and number of active sites), assessed as motor evoked potentials induced by transcranial magnetic stimulation in primary motor cortex (M1); iii) Reduction of alpha oscillation based on nociceptive stimulus-evoked suppression of alpha activity in sensory regions (recording electrodes on contra-lateral parietal area);

Conditions

• Nerve Growth Factor
• Exercise
• Motor Activity
• Abnormality of SSEPs
• Hyperalgesia

Interventions

Type	Name	Description
DRUG	Sterile solutions of recombinant human nerve growth factor (NGF)	The intramuscular injections of NGF cause muscle soreness.

Timeline

• Start date: 2017-11-26
• Primary completion: 2018-02-28
• Completion: 2018-02-28
• First posted: 2017-11-28
• Last updated: 2018-03-05

Locations

1 site across 1 country: Denmark