NCT03349606

Cocaine Use Disorder and Cortical Dopamine

Imaging of Cortical Dopamine Transmission in Cocaine Dependence

• Status: Completed
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: University of Pittsburgh · Academic / Other
• Sex: All
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

The goal of this study is to use \[C-11\]FLB 457 and amphetamine (oral, 0.5 mg/kg) to measure cortical dopamine transmission in cocaine dependent individuals and healthy controls

Detailed description

This study seeks to examine dopamine (DA) transmission in vivo, using positron emission tomography (PET) with \[C-11\]FLB 457, in cortical regions of interest in subjects who have a history of cocaine dependence. We hypothesize that cocaine dependence is associated with decreases in dopamine in the prefrontal cortical regions compared to controls. This may explain the impulsivity and cognitive deficits that underlie relapse in this disorder.

Conditions

• Cocaine Dependence

Interventions

Type	Name	Description
DRUG	d-amphetamine	oral d- amphetamine 0.5 mg/kg is used to stimulate dopamine release in the brain
RADIATION	[C-11]FLB 457	PET radiotracer

Timeline

• Start date: 2010-06-02
• Primary completion: 2019-09-24
• Completion: 2020-06-01
• First posted: 2017-11-21
• Last updated: 2020-06-04

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study