NCT03335696

Predicting MRI Abnormalities With Longitudinal Data of the Whitehall II Substudy

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 800 (actual)
• Sponsor: University of Oxford · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Accepted

Summary

Follow-up study within the Whitehall II study, selecting 800 participants for further neuropsychological, clinical and imaging (MRI) examinations to examine brain structure and function in relation to age-related diseases and the modifiable and non-modifiable factors affecting resilience against and vulnerability to adverse brain changes.

Detailed description

A total of 6035 civil servants participated in the WHII Phase 11 clinical examination in 2012-2013. A random sample of 800 of these participants was included in a sub-study comprising an MRI brain scan, a detailed clinical and cognitive assessment, and collection of blood and buccal mucosal samples for the characterisation of immune function and associated measures. Data collection for this sub-study started in 2012 and was completed by in 2016. The participants, for whom social and health records have been collected since 1985, were between 60-85 years of age at the time the MRI study started. The pre-specified clinical and cognitive assessment protocols, the state-of-the-art MRI sequences and latest pipelines for analyses of this sub-study have been published and are attached to this application.

Conditions

• Cognitive Impairment
• Dementia
• Affective Disorders

Timeline

• Start date: 2012-01-01
• Primary completion: 2017-06-30
• Completion: 2017-06-30
• First posted: 2017-11-08
• Last updated: 2023-12-05

Locations

1 site across 1 country: United Kingdom