NCT03330470

Molecular Mediators of Physical Exercise and Carnosine Induced Effects in Patients With Preclinical and Early Stage Neurodegenerative Disease

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 26 (actual)
• Sponsor: Slovak Academy of Sciences · Other Government
• Sex: All
• Age: 55 Years – 80 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to investigate the beneficial effects of regular exercise and the impact of food supplement carnosine on cognitive, motoric and metabolic functions as well as on specific biologically active substances in volunteers with subjective (SCI) or mild (MCI) cognitive impairment, as well as in patients in early stages of Parkinson's disease. The investigators assume the immediate intervention-associated health benefit for volunteers.

Detailed description

Standard Operating Procedures for patient recruitment, data collection, data management, data analysis routinely used in Biomedical Research Center, Slovak Academy of Sciences, University Hospital Bratislava and Comenius University, Bratislava will be employed. Gait and balance parameters will be examined and analysed at the Department of Behavioural Neuroscience, Centre of Experimental Medicine, Slovak Academy of Sciences, Bratislava, Slovakia Statistical analysis will be employed to address the primary and secondary objectives, as specified in the study protocol.

Conditions

• Subjective Cognitive Impairment
• Mild Cognitive Impairment
• Parkinson Disease
• Healthy Volunteers

Interventions

Type	Name	Description
BEHAVIORAL	exercise	participants will be subjected to 4 months supervised exercise intervention
DIETARY_SUPPLEMENT	carnosine supplementation	participants will be instructed to take carnosine 2 times daily
BEHAVIORAL	stretching	participants will be subjected to 4 months supervised stretching program
DIETARY_SUPPLEMENT	supplementation with placebo	participants will be instructed to take placebo 2 times daily

Timeline

• Start date: 2017-01-01
• Primary completion: 2023-06-30
• Completion: 2023-09-30
• First posted: 2017-11-06
• Last updated: 2025-05-28

Locations

3 sites across 2 countries: Slovakia, Taiwan