NCT03318042

Genotype, Metabotype and Diet in a Cohort of Children and Adolescents From the Southeast of Spain.

Association Between Genotype, Polyphenol Gut Microbiota Metabotypes, and Diet in a Cohort of Children and Adolescents From the Southeast of Spain.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 423 (actual)
• Sponsor: National Research Council, Spain · Other Government
• Sex: All
• Age: 5 Years – 18 Years
• Healthy volunteers: Accepted

Summary

The objective of this study is to investigate the possible association between 60 SNPs related to obesity, metabolism and cardiovascular disease with BMI, intestinal microbiota and adherence to the Mediterranean diet in a cohort of children and adolescents from the southeast of Spain.

Detailed description

The objective of this study is to investigate the possible association between 60 single nucleotide polymorphisms (SNPs) related to obesity, metabolism and cardiovascular disease with the body mass index (BMI), intestinal microbiota related to the metabolism of polyphehnos and adherence to the Mediterranean diet in a cohort of children and adolescents from the southeast of Spain. The volunteers (n=423) with ages ranging from 5 to 18 years consumed for three days a daily serving of walnuts (30g) and provided a sample of urine (to determine mirobial-derived metabolites from walnut polyphenols) as well as a swab specimen from the inner cheek to provide DNA for further genotyping.

Conditions

• Genotype, Metabotype and Dietary Habits

Interventions

Type	Name	Description
OTHER	Walnuts	The group consumed a daily serving of walnuts (30 g) or 200 mL pomegranate juice for 3 days and provided a sample of urine as well as a swab specimen from the inner cheek
OTHER	Pomegranate juice	Those volunteers who were allergic to nuts consumed 200 mL pomegranate juice daily for 3 days and provided a sample of urine as well as a swab specimen from the inner cheek

Timeline

• Start date: 2016-02-01
• Primary completion: 2016-05-01
• Completion: 2016-11-02
• First posted: 2017-10-23
• Last updated: 2017-10-24

Locations

1 site across 1 country: Spain