Trials / Completed
CompletedNCT03301519
Genetics of Beta Cell Failure in Mexican Americans
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 1,250 (actual)
- Sponsor
- University of Southern California · Academic / Other
- Sex
- All
- Age
- 8 Years
- Healthy volunteers
- Not accepted
Summary
This is a family based genotype-phenotype study designed to assess genetic and environmental influences on obesity, insulin resistance and beta cell function in the context of gestational diabetes.
Detailed description
Mexican American women with prior gestational diabetes and their first degree relatives and Mexican American women with prior normal glucose tolerance in pregnancy are studied with detailed phenotyping consisting of oral and intravenous glucose tolerance tests, body composition studies, diet and physical activity assessments, and circulating biomarkers potentially related to obesity, insulin resistance, pancreatic beta cell function, gestational diabetes and type 2 diabetes. Spouses of the gestational diabetic and control probands are studied with oral glucose tolerance tests. Offspring of the gestational and control probands have fasting glucose determinations. All participants provide DNA for genetics testing. A subset of the gestational diabetic probands and their first degree relatives return 3-5 years after baseline testing for repeat phenotyping.
Conditions
- Gestational Diabetes
- Diabetes Type 2
- Insulin Resistance
- Beta Cell Function
- Genetics
- Nutrition
- Physical Activity
- Adipokines
- Obesity
- Air Pollution
Timeline
- Start date
- 2001-07-01
- Primary completion
- 2013-05-31
- Completion
- 2013-05-31
- First posted
- 2017-10-04
- Last updated
- 2023-11-18
Source: ClinicalTrials.gov record NCT03301519. Inclusion in this directory is not an endorsement.