NCT03298802

Postpartum Management of Hypertension in Pregnancy With Hydrochlorothiazide

Postpartum Management of Hypertension in Pregnancy With Hydrochlorothiazide: a Randomized Clinical Trial

• Status: Unknown
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 612 (estimated)
• Sponsor: The University of Texas Medical Branch, Galveston · Academic / Other
• Sex: Female
• Age: 18 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

Postpartum prophylactic HCTZ administration for prevention and relapse of preeclampsia or gestational hypertension.

Detailed description

To evaluate effectiveness of hydrochlorothiazide prophylaxis on prophylaxis, prevention and relapse of preeclampsia or gestational hypertension on readmission rates, need for additional antihypertensive therapy and number of triage visits.

Conditions

• Pre-Eclampsia
• Gestational Hypertension
• Superimposed Pre-Eclampsia
• Hypertension, Pregnancy-Induced
• Postpartum Pregnancy-Induced Hypertension
• Postpartum Preeclampsia

Interventions

Type	Name	Description
DRUG	Hydrochlorothiazide 50mg Tablet	Hydrochlorothiazide 50 mg per os once daily as soon as the subjects can tolerate sips of water after delivery and for a total of fourteen days postpartum.
DRUG	Placebo Tablet	Placebo per os once daily as soon as the subjects can tolerate sips of water after delivery and for a total of fourteen days postpartum

Timeline

• Start date: 2017-11-21
• Primary completion: 2024-08-30
• Completion: 2024-08-30
• First posted: 2017-10-02
• Last updated: 2023-12-05

Locations

2 sites across 1 country: United States

Regulatory

• FDA-regulated drug study