NCT03297411

Clinical Outcomes With Electroconvulsive Therapy: Insights From Computational Modelling

• Status: Unknown
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 15 (estimated)
• Sponsor: The University of New South Wales · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study will generate new information on how to optimise brain targets with ECT stimulation.

Detailed description

This study will differentiate the brain regions which are related to the effectiveness of electroconvulsive therapy (ECT) as a treatment, from the brain regions associated with memory impairment, with ECT stimulation. This will be done by 1) testing effects on memory of 4 different forms of ECT, which stimulate the brain differently; 2) in a subset of participants, use computer modelling to assess the pattern of brain stimulation with the 4 forms of ECT, and match these results to memory outcomes.

Conditions

• Depression

Interventions

Type	Name	Description
PROCEDURE	Brief Temporoparietal ECT	Electroconvulsive Therapy (Brief pulse width, Temporoparietal) The intervention in this study is different combinations of pulse width and ECT electrode placements.
PROCEDURE	Ultrabrief Temporoparietal ECT	Electroconvulsive Therapy (Ultrabrief pulse width, Temporoparietal) The intervention in this study is different combinations of pulse width and ECT electrode placements.
PROCEDURE	Brief Frontoparietal ECT	Electroconvulsive Therapy (Brief pulse width, Frontoparietal) The intervention in this study is different combinations of pulse width and ECT electrode placements.
PROCEDURE	Ultrabrief Frontoparietal ECT	Electroconvulsive Therapy (Ultrabrief pulse width, Frontoparietal) The intervention in this study is different combinations of pulse width and ECT electrode placements.

Timeline

• Start date: 2017-10-10
• Primary completion: 2022-06-22
• Completion: 2022-06-22
• First posted: 2017-09-29
• Last updated: 2018-05-16

Locations

1 site across 1 country: Australia