NCT03287115

Biomarkers of Broccoli Intake: A Pilot Study

Biomarkers of Broccoli Intake: A Pilot Study to Characterize Novel Metabolites by Targeted Metabolic Profiling and Non-Targeted Metabolomics

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 6 (actual)
• Sponsor: USDA Beltsville Human Nutrition Research Center · Federal
• Sex: All
• Age: 21 Years – 70 Years
• Healthy volunteers: Accepted

Summary

The objectives of the study are 1) to characterize plasma and urinary metabolites that originate from glucobrassicin, 1-methoxyglucobrassicin, 4-methoxyglucobrassicin, and 4-hydroxyglucobrassicin, which are the major indole glucosinolates found in broccoli, and 2) to identify novel plasma and urinary metabolites following broccoli consumption that may have roles in reducing the risk of cancer.

Detailed description

Consumption of Brassica vegetables is inversely associated with incidence of several cancers, including cancer of the lung, stomach, liver, colon, rectum, breast, endometrium, and ovaries. Brassicas are a good source of many nutrients, but the unique characteristic of Brassicas is their rich content of glucosinolates. Breakdown products of indole glucosinolates in Brassica vegetables show promise for reducing the risk of cancer, but have received comparatively less research attention than those of aliphatic glucosinolates. The aim of this study is to investigate plasma and urinary metabolites of indole glucosinolates from broccoli and to identify novel metabolites that may have roles in reducing cancer risk.

Conditions

• Healthy Volunteers

Interventions

Type	Name	Description
OTHER	Broccoli consumption	All subjects will eat broccoli on day 11

Timeline

• Start date: 2017-11-06
• Primary completion: 2017-11-17
• Completion: 2017-11-17
• First posted: 2017-09-19
• Last updated: 2017-11-21

Locations

1 site across 1 country: United States