Trials / Completed
CompletedNCT03278769
Ventilator Settings on Patients With Acute Brain Injury
Relation Between Lung Protective Mechanical Ventilation, Intracranial Pressure, Autoregulation and Brain Oxygenation in Neurointensive Care Patients
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 27 (actual)
- Sponsor
- University Hospital of North Norway · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
The present study is an explorative analysis of the relationship between cerebral blood perfusion and oxygenation and lung mechanical variables at different ventilator settings. It is a safety study excluding patients with severe lung injury or brain edema.
Detailed description
The primary goal is to carry out baseline measurements to enable conclusions concerning the safety of lung protective ventilator settings before extending the study to patients with more severe brain and/or lung injury in the future. The primary objective is to investigate if lung protective ventilator settings (higher Positive end-expiratory pressure and lower tidal volume) as compared with conventional settings. 1. increase intracranial pressure 2. diminish cerebral vasoreactive autoregulation as assessed by pressure reactivity index, ie pressure reactivity index will turn positive, which means that it will change the state from intact to impaired autoregulation. The secondary objective is an exploratory analysis of the relationship between ventilator settings and other well defined respiratory, cerebral, and cardiovascular variables, including transpulmonary pressure.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | Lung protective ventilator settings | Positive end-expiratory pressure 12, Tidal volume 6 milliliter/kilogram predicted body weight |
Timeline
- Start date
- 2019-06-01
- Primary completion
- 2021-09-01
- Completion
- 2022-01-01
- First posted
- 2017-09-12
- Last updated
- 2022-05-23
Locations
1 site across 1 country: Norway
Source: ClinicalTrials.gov record NCT03278769. Inclusion in this directory is not an endorsement.