NCT03266939

Rebalancing the Serotonergic System in Cocaine Dependence

• Status: Withdrawn
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: Mclean Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 55 Years
• Healthy volunteers: Not accepted

Summary

In the United States, 1.5 million people abuse cocaine leading to a host of negative health and economic consequences, yet no FDA approved treatment exists. To develop effective treatments, the following must be considered: 1) do potential medications ameliorate brain disruptions associated with cocaine use? 2) are multiple, targeted treatments necessary? To meet these goals, innovative multi-modal neuroimaging will be used to determine whether rebalancing the serotonergic (5-HT) system reduces cocaine cue reactivity, impulsivity, and normalizes related neurochemistry and brain connectivity.

Conditions

• Cocaine Dependence

Interventions

Type	Name	Description
DRUG	Lorcaserin	10 mg acute administration of lorcasein
DRUG	Placebo Oral Tablet	Placebo

Timeline

• Start date: 2018-10-04
• Primary completion: 2018-10-04
• Completion: 2018-10-04
• First posted: 2017-08-30
• Last updated: 2025-10-20

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study