NCT03265015

Theta Burst Stimulation for Compulsive Behavior Non-invasive Brain Stimulation Study

Testing the Causal Role of Orbitofrontal Cortex in Human Compulsive Behavior: a Non-invasive Brain Stimulation Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 78 (actual)
• Sponsor: University of Pittsburgh · Academic / Other
• Sex: All
• Age: 18 Years – 55 Years
• Healthy volunteers: Not accepted

Summary

This project seeks to identify causal neural mechanisms underlying unwanted, repetitive behaviors (compulsions). Using non-invasive brain stimulation coupled with practice in a computer task, we will modulate activity in a target brain region in two directions (up or down) and measure effects on compulsive behaviors and related measures. This work could ultimately lead to the ability to treat compulsions more effectively by targeting the regions of the brain that can help or hinder attempts to overcome compulsions.

Conditions

• Compulsive Behavior
• Obsessive-Compulsive Disorder

Interventions

Type	Name	Description
BEHAVIORAL	Habit Override Practice	Computerized "brain training" to provide practice in overriding avoidance habits.
OTHER	Transcranial Magnetic Stimulation	Non-invasive method for temporary, focal stimulation of brain areas.

Timeline

• Start date: 2017-09-15
• Primary completion: 2020-03-30
• Completion: 2020-03-30
• First posted: 2017-08-29
• Last updated: 2022-08-16

Locations

1 site across 1 country: United States