Trials / Completed
CompletedNCT03253939
Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy in Peritoneal Carcinomatosis From Gastric Cancer
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 275 (actual)
- Sponsor
- Hospices Civils de Lyon · Academic / Other
- Sex
- All
- Age
- 18 Years – 95 Years
- Healthy volunteers
- Not accepted
Summary
Gastric cancer associated peritoneal carcinomatosis has a poor prognosis with a median survival of less than one year. Systemic chemotherapy including targeted agents has not been found to significantly increase the survival in Gastric cancer associated peritoneal carcinomatosis. Since recurrent gastric cancer remains confined to the abdominal cavity in many patients, regional therapies like aggressive cytoreductive surgery and hyperthermic intraperitoneal chemotherapy have been investigated for Gastric cancer associated peritoneal carcinomatosis. Hyperthermic intraperitoneal chemotherapy has been used for three indications in Gastric Cancer- as an adjuvant therapy after a curative surgery, hyperthermic intraperitoneal chemotherapy has been shown to improve survival and reduce peritoneal recurrences in many randomised trials in Asian countries; as a definitive treatment in established PC, hyperthermic intraperitoneal chemotherapy along with cytoreductive surgery is the only therapeutic modality that has resulted in long-term survival in select groups of patients. While the results of randomised trials of adjuvant hyperthermic intraperitoneal chemotherapy from western centres are awaited, the role of hyperthermic intraperitoneal chemotherapy in the treatment of Gastric cancer associated peritoneal carcinomatosis is still evolving and needs larger studies before it is accepted as a standard of care.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | Cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy procedure | Cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy procedure |
| PROCEDURE | Cytoreductive surgery alone | Exclusively Cytoreductive surgery approach |
Timeline
- Start date
- 2017-02-01
- Primary completion
- 2017-07-01
- Completion
- 2017-07-01
- First posted
- 2017-08-18
- Last updated
- 2017-08-18
Locations
1 site across 1 country: France
Source: ClinicalTrials.gov record NCT03253939. Inclusion in this directory is not an endorsement.