NCT03253926

Effect of Lorcaserin on Cannabis Withdrawal and Self-administration

• Status: Completed
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 15 (actual)
• Sponsor: New York State Psychiatric Institute · Academic / Other
• Sex: All
• Age: 21 Years – 50 Years
• Healthy volunteers: Accepted

Summary

In this study, the investigators are interested in testing how lorcaserin influences the effects of cannabis in a human laboratory model of cannabis use.

Detailed description

In order to improve treatment outcome for cannabis use disorder (CUD), the investigators have developed a laboratory model to investigate the effects of potential treatment medications on cannabis withdrawal and on the subjective and reinforcing effects of cannabis in non treatment-seeking cannabis smokers. In this study, the investigators are interested in testing how lorcaserin influences the effects of cannabis in a human laboratory model of cannabis use.

Conditions

• Cannabis Use

Interventions

Type	Name	Description
DRUG	Lorcaserin	Lorcaserin 10mg BID
DRUG	Placebo	Placebo capsule BID
DRUG	Marijuana	Smoked marijuana cigarette

Timeline

• Start date: 2017-09-05
• Primary completion: 2021-05-31
• Completion: 2021-12-31
• First posted: 2017-08-18
• Last updated: 2022-07-26
• Results posted: 2022-07-26

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study