NCT03248076

Effect of Fentanyl on Main Opioid Receptor (OPRM1) on Human Granulosa Cells.

Effect of Fentanyl on Expression of Main Opioid Receptor (OPRM1) on Human Granulosa Cells During Ultrasound-guided Transvaginal Oocyte Retrieval.

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 30 (estimated)
• Sponsor: George Papanicolaou Hospital · Academic / Other
• Sex: Female
• Age: 18 Years – 32 Years
• Healthy volunteers: Accepted

Summary

Opioids is known that produce not only analgesia but also hyperalgesia through activation of central glutaminergic system-GABA. At the same time, recently it was found that the main opioid receptor (OPRM1) is present on human granulosa cells and exogenous opiates and their antagonists can influence granulosa cell vascular endothelial growth factor (VEGF) production via OPRM1, causing ovarian hyperstimulation syndrome. This study aims to investigate if a single exposure to opioids is enough to produce activation of stress mechanism during oocyte retrieval.

Detailed description

The main opioid receptor (OPRM1) is present on human granulosa cells and exogenous opiates and their antagonists can influence granulosa cell vascular endothelial growth factor (VEGF) production via OPRM1, causing ovarian hyperstimulation syndrome. This study aims to investigate if a single exposure to opioids is enough to produce activation of stress mechanism during ultrasound-guided oocyte retrieval. It will be measured the level of cortisone before and 15min after iv administration of fentanyl on blood and on oocyte fluid.

Conditions

• Stress Reaction
• Opioid Use

Interventions

Type	Name	Description
DRUG	Fentanyl Citrate	1γ/Kg fentanyl

Timeline

• Start date: 2017-04-01
• Primary completion: 2018-08-31
• Completion: 2018-10-10
• First posted: 2017-08-14
• Last updated: 2017-12-14

Locations

1 site across 1 country: Greece