NCT03228693

Gene Expression and Biomarker Profiling of Keloid Skin

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 48 (actual)
• Sponsor: Northwestern University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

This study aims to examine both the genetic profile and the biomarkers implicated in keloid scar formation. Hypothesis: 1. Differences in the genetic profiles of lesional and non-lesional skin contribute a given population's propensity to develop keloids 2. Differences in biomolecules expressed in subjects with and without keloids can help predict keloid occurrence and severity 3. Biomarker analysis will provide useful insights for future targeted therapies for keloid scars

Detailed description

Objectives: 1. Determine gene expression profiles of keloid scar tissue using samples collected longitudinally 2. Define and compare the molecular biomarkers of keloid scars in keloid (lesional) and non-lesional skin biopsies and serum samples from adult subjects

Conditions

• Keloid
• Keloid of Ear Lobe
• Healthy Adults

Interventions

Type	Name	Description
PROCEDURE	Biopsy and/or triamcinolone injection	Subjects will have their blood drawn during the first study visit. Subsequently, a punch biopsy and/or triamcinolone injection will be given based on group timeline.
PROCEDURE	Excisional Biopsy	Complete excision of an earlobe keloid will be taken.

Timeline

• Start date: 2017-09-11
• Primary completion: 2021-09-02
• Completion: 2023-01-31
• First posted: 2017-07-25
• Last updated: 2023-03-29

Locations

1 site across 1 country: United States