NCT03217942

Spread of Muscle Hyperalgesia and Pain in a Low Dose NGF-induced Pain Model

• Status: Completed
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: Aalborg University · Academic / Other
• Sex: All
• Age: 18 Years – 55 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to investigate and determine the time course and distribution on muscle hyperalgesia and muscle pain in a repeated, low dose NGF model. It is hypothesized that low dosages i.m injections of NGF are able to induce mechanical hyperalgesia and muscle soreness in a same manner (effect of duration) as for dosages previously used in NGF studies. Furthermore, it is also speculated if several injections of low dose NGF into the muscle combined are able to course immediate pain sensation and spreading of muscle hypersensitivity.

Detailed description

Effects of pain responses, symptom development and pattern (time course and distribution) following 5 i.m low dose injections of NGF injected into the tibialis anterior muscle will be compared to a high dose i.m injection of NGF injected into the contralateral side in healthy pain-free subjects.

Conditions

• Hyperalgesia
• Healthy Subjects

Interventions

Type	Name	Description
DRUG	NGF	Intramuscular injection

Timeline

• Start date: 2017-07-01
• Primary completion: 2017-10-01
• Completion: 2017-10-01
• First posted: 2017-07-14
• Last updated: 2018-01-11

Locations

1 site across 1 country: Denmark