NCT03216850

Evaluation of Lipid Emulsion on GCX in Critically Ill Patients

Alterations of Glycocalyx in Critical Illness and During Major Surgery and Approaches for Glycocalyx Protection. Effect of Parenteral Nutrition and Plasma Lipidome on GCX

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 15 (actual)
• Sponsor: University Hospital Hradec Kralove · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: —

Summary

Characterisation of the lipidome and parenteral nutrition modulate the endothelial glycocalyx. The aim of the study A is to detect any influence of the lipid emulsion on the endothelial glycocalyx in patients in critical care. The targeted cohort is patients on ICU with an indication for parenteral nutrition including lipid emulsion. 15 patients are planned to be enrolled. Monitored variables: demographic data, type of the population, type of the lipid emulsion, selected variables of the lipid metabolism, sublingual microcirculation (SDF imaging),

Conditions

• Endothelial Dysfunction

Interventions

Type	Name	Description
DEVICE	Sublingual microcirculation assessment	Non-invasive investigation of the endothelial glycocalyx in the sublingual microcirculation.

Timeline

• Start date: 2018-01-01
• Primary completion: 2018-08-31
• Completion: 2018-12-31
• First posted: 2017-07-13
• Last updated: 2019-11-27
• Results posted: 2019-11-27

Locations

1 site across 1 country: Czechia