NCT03212430

The Effect of Intravenous L-kynurenine (LKYN) on Cerebral Hemodynamics in Healthy Volunteers

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 6 (actual)
• Sponsor: Danish Headache Center · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Accepted

Summary

To measure the cerebral hemodynamic effect of L-kynurenine.

Detailed description

Aim: To investigate the physiological effect of L-Kynurenine after intravenous administration to healthy volunteers. Hypothesis: L-kynurenine induces vasodilation in the cerebral vessels and trigger headache in healthy individuals. Methods: 6 healthy volunteers will receive intravenous infusion of L-kynurenine using the following doses 50 microgram/kg, 100 microgram/kg, 150 microgram/kg, 300 microgram/kg, 500 microgram/kg, 1 mg/kg and 5 mg/kg over 20 min on 7 different days with at least 1 day in between. Before and after infusion (at 20, 40, 60, 80 and 100 min) we will record vital signs, circumferences of middle cerebral artery, superficial temporalis artery and headache intensity and characteristics. The subjects will then have a questionnaire about headache for the following 24 hours.

Conditions

• Headache

Interventions

Type	Name	Description
DRUG	L-kynurenine	intravenous infusion of L-kynurenine to healthy individuals.

Timeline

• Start date: 2017-03-01
• Primary completion: 2019-01-20
• Completion: 2019-01-20
• First posted: 2017-07-11
• Last updated: 2019-01-23

Locations

1 site across 1 country: Denmark