NCT03204669

Trace Element Repletion Following Severe Burn Injury

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 139 (actual)
• Sponsor: Centre Hospitalier Universitaire Vaudois · Academic / Other
• Sex: All
• Age: 14 Years – 86 Years
• Healthy volunteers: Not accepted

Summary

Major burn patients are characterized by large exudative losses of Cu, Se and Zn. Trace element (TE) repletion has been shown to improve clinical outcome. The study aimed to check if our repletion protocols were achieving normalization of TE plasma concentrations of major burn patients and if the necessity for continuous renal replacement therapy (CRRT) might increase the needs.

Detailed description

Retrospective analysis of prospectively collected data in burn patients requiring intensive care (ICU) between 1999 and 2015. The cohort was divided into 4 groups according to the protocol changes. Period 1 (P1): 1999-2000, P2: 2001-2005, P3: 2006-2010, P4: 2011-2015. Changes consisted mainly in increasing TE repletion doses and duration. Demographic data, daily TE intakes and weekly plasma concentrations were retrieved for the first 21 ICU-days.

Conditions

• Critical Illness
• Nutritional Deficiency
• Trace Element Deficiency
• Burn Injury

Interventions

Type	Name	Description
OTHER	Trace elements replacement

Timeline

• Start date: 1999-06-01
• Primary completion: 2015-12-31
• Completion: 2015-12-31
• First posted: 2017-07-02
• Last updated: 2017-07-02

Locations

1 site across 1 country: Switzerland