NCT03204526

Low Frequency Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson's Disease

Safety and Feasibility of Using Low Frequency Deep Brain Stimulation of the Subthalamic Nucleus to Improve Cognitive Performance in Patients With Parkinson's Disease

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 15 (actual)
• Sponsor: University of California, Davis · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Prospective trial of low frequency deep brain stimulation of the ventral subthalamic nucleus to improve cognitive performance in patients with advanced Parkinson's disease. All study participants have undergone DBS implantation surgery as part of their routine care for motor manifestations of Parkinson's disease. In this study, a temporary low frequency period of stimulation will be applied to determine its effects on cognition.

Detailed description

In this randomized cross-over pilot study, our primary aim was to determine the effect of theta (5 Hz), and gamma (130 Hz) frequency stimulation in the ventral STN on cognitive control in patients with PD. This study provides a first look at frequency dependent modulation of cognitive function and provides important insights into the utility of DBS for non-motor symptoms of PD and other neuropsychiatric disorders.

Conditions

• Parkinson Disease
• Cognitive Impairment

Interventions

Type	Name	Description
DEVICE	deep brain stimulation

Timeline

• Start date: 2015-06-01
• Primary completion: 2019-11-01
• Completion: 2019-11-01
• First posted: 2017-07-02
• Last updated: 2021-06-23
• Results posted: 2021-06-23

Locations

1 site across 1 country: United States