NCT03202914

Metabolomics for Identifying Biomarkers of Dietary Intake and Kidney Disease Progression

Metabolomics for Identifying Biomarkers of Dietary Intake and Kidney Disease Progression: A Secondary Data Analysis of the Modification of Diet in Renal Disease (MDRD) Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 840 (actual)
• Sponsor: Johns Hopkins Bloomberg School of Public Health · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

The present record represents a secondary data analysis of the Modification of Diet in Renal Disease (MDRD) Study. For this analysis, the MDRD study data and specimens were retrieved from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Central Repository. A global, untargeted, metabolomic profile was used to investigate biomarkers of dietary intake as well as biomarkers of kidney disease progression.

Detailed description

The present study was conducted in order to: 1) quantify the metabolomic expression of dietary intake; and 2) examine the relationship between metabolites that reflect dietary intake and kidney disease progression. This secondary data analysis leverages the completed Modification of Diet in Renal Disease (MDRD) study, a randomized clinical trial of dietary protein restriction (N=840).

Conditions

• Dietary Modification
• Kidney Diseases, Chronic

Interventions

Type	Name	Description
BEHAVIORAL	Usual protein and phosphorus diet	Diet intervention
BEHAVIORAL	Low protein and phosphorus diet	Diet intervention
BEHAVIORAL	Very low protein and phosphorus	Diet intervention

Timeline

• Start date: 1988-10-01
• Primary completion: 1993-05-01
• Completion: 2016-01-01
• First posted: 2017-06-29
• Last updated: 2017-06-29

Locations

1 site across 1 country: United States