Trials / Completed
CompletedNCT03202823
Arachidonic Acid Metabolism in Carotid Stenosis Plaque in Diabetic Patients
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 204 (actual)
- Sponsor
- Centre Hospitalier Universitaire Dijon · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
Diabetes is associated with an increased risk of cardiovascular complications, as a reflection of the chronic inflammatory status. Monocytes-macrophages in diabetic subjects present impaired arachidonic acid metabolism. Moreover, atheromatous plaques in diabetic subjects seem to be significantly enriched in 2-AA-LPC (2-arachidonoyl-lysophosphatidylcholine) and are more inflammatory and more likely to rupture than are plaques in non-diabetic subjects. We therefore hypothesize that this vulnerability of atheromatous plaques in diabetic subjects could be explained by impaired 2-AA-LPC metabolism within the plaque.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | blood samples | 3 tubes (5 ml volume) collected during surgery |
| PROCEDURE | recover samples of atheromatous plaque | a carotid sample collected during surgery |
Timeline
- Start date
- 2017-04-13
- Primary completion
- 2020-12-11
- Completion
- 2020-12-11
- First posted
- 2017-06-29
- Last updated
- 2026-02-09
Locations
1 site across 1 country: France
Source: ClinicalTrials.gov record NCT03202823. Inclusion in this directory is not an endorsement.